|
KMID : 0606920140220010041
|
|
Biomolecules & Therapeutics
2014 Volume.22 No. 1 p.41 ~ p.46
|
|
|
Antiviral Activity of Hederasaponin B from Hedera helix against Enterovirus 71 Subgenotypes C3 and C4a
|
|
Song Jae-Hyoung
Yeo Sang-Gu
Hong Eun-Hye
Lee Bo-Ra
Kim Jin-Won
Kim Jeong-Hoon
Jeong Hyeon-Gun
Kwon Yong-Soo
Kim Hyun-Pyo
Lee Sang-Won
Park Jae-Hak
Ko Hyun-Jeong
|
|
|
Abstract
|
|
|
|
Enterovirus 71 (EV71) is the predominant cause of hand, foot and mouth disease (HFMD). The antiviral activity of hederasaponin B from Hedera helix against EV71 subgenotypes C3 and C4a was evaluated in vero cells. In the current study, the antiviral activity of hederasaponin B against EV71 C3 and C4a was determined by cytopathic effect (CPE) reduction method and western blot assay. Our results demonstrated that hederasaponin B and 30% ethanol extract of Hedera helix containing hederasaponin B showed significant antiviral activity against EV71 subgenotypes C3 and C4a by reducing the formation of a visible CPE. Hederasaponin B also inhibited the viral VP2 protein expression, suggesting the inhibition of viral capsid protein synthesis.These results suggest that hederasaponin B and Hedera helix extract containing hederasaponin B can be novel drug candidates with broad-spectrum antiviral activity against various subgenotypes of EV71.
|
|
|
KEYWORD
|
|
|
Enterovirus 71, Antiviral activity, Hederasaponin B, Hedera helix, Hand foot and mouth disease
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
  
|